These factors act on cartilage by inhibiting proteoglycan synthesis and stimulating its destruction, creating a feedback loop. It is known that the accumulation of articular cartilage matrix degradation products stimulates the release of inflammatory mediators, such as cytokines (IL-1β, IL-6 and TNF-α) and prostaglandin E2 (PGE-2), from the synovium and subchondral bones. Today, it is considered a more complex process, with metabolic and inflammatory factors. The pathophysiology of OA has been considered a process of prolonged and repeated wear and tear of the articular cartilage with alterations in subchondral bone metabolism (sclerosis) and new bone formation at the joint margins (osteophytes). Osteoarthritis (OA) is a slowly progressive and dynamic degenerative disease that affects mobile joints. In conclusion, undenatured type II collagen and Boswellia serrata are considered a valid option for the multimodal approach to the management of OA and for improving activity during intense exercise, but more studies are needed to conclude whether or not it prevents OA in dogs. The combination of both in the same product provides results similar to those obtained in undenatured type II collagen studies. Evaluating the response to supplementation with Boswellia serrata alone is complicated due to the limited publication of studies and variations in the purity and compositions of the products used, but in general terms, its combination with other feed supplements produces benefits by relieving pain and reducing the clinical signs of OA in dogs. The review of the records showed that undenatured type II collagen decreases the clinical signs associated with OA, improving the general clinical state with a reduction in the degree of lameness and increase in physical activity or mobility. For this purpose, a literature review was carried out using the electronic databases PubMed, Web of Science and Google Scholar, from which a total of 26 records were included in this review: fourteen evaluating undenatured type II collagen, ten evaluating Boswellia serrata and two evaluating the combination of undenatured type II collagen and Boswellia serrata. The aim of this scoping review is to present the results found in the veterinary literature on the use of undenatured type II collagen and Boswellia serrata in dogs, specifically its use in dogs with clinical signs of OA, healthy dogs after intense exercise or dogs with diseases that predispose the individual to OA. It does not store any personal data.In the multimodal management of osteoarthritis (OA) in recent decades, the use of feed supplements to maintain joint cartilage has been advocated. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary". ![]() The cookie is used to store the user consent for the cookies in the category "Other. ![]() ![]() The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". ![]() The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly.
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